Longitudinal survey of knockdown resistance to pyrethroid (kdr) in Mali, West Africa, and evidence of its emergence in the Bamako form of Anopheles gambiae s.s.
Am J Trop Med Hyg
; 76(1): 81-7, 2007 Jan.
Article
em En
| MEDLINE
| ID: mdl-17255234
ABSTRACT
Studies aimed at monitoring the spread of knockdown resistance to pyrethroids (kdr) in time and space are particularly useful for detecting barriers to gene flow among the chromosomal and molecular forms of Anopheles gambiae. We used a recently developed polymerase chain reaction assay to estimate changes in kdr frequency that occurred in several mixed-form populations from Mali, West Africa, in the past decade. We found that the kdr allele significantly increased in frequency in most populations but was still absent from the M molecular form. Importantly, within the S molecular form, kdr was detected for the first time in the Bamako chromosomal form. These results provide important insights on the patterns of spread and emergence of pyrethroid knockdown resistance in West Africa.
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Base de dados:
MEDLINE
Assunto principal:
Piretrinas
/
Resistência a Inseticidas
/
Anopheles
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article