Adaptive bolus-based set-point regulation of hyperglycemia in critical care.
Conf Proc IEEE Eng Med Biol Soc
; 2004: 3463-6, 2004.
Article
em En
| MEDLINE
| ID: mdl-17271031
ABSTRACT
Critically ill patients are often hyperglycemic and extremely diverse in their dynamics. Consequently, fixed protocols and sliding scales can result in error and poor control. A two-compartment glucose-insulin system model that accounts for time-varying insulin sensitivity and endogenous glucose removal, along with two different saturation kinetics is developed and verified in proof-of-concept clinical trials for adaptive control of hyperglycemia. The adaptive control algorithm monitors the physiological status of a critically ill patient, allowing real-time tight glycemic regulation. The bolus-based insulin administration approach is shown to result in safe, targeted stepwise glycemic reduction for three critically ill patients.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article