Phenylacetate and benzoate clearance in a hyperammonemic infant on sequential hemodialysis and hemofiltration.
Pediatr Nephrol
; 22(7): 1062-5, 2007 Jul.
Article
em En
| MEDLINE
| ID: mdl-17277951
ABSTRACT
An infant with a suspected inborn metabolism error was treated with a metabolic cocktail of intravenous sodium phenylacetate (NaPh) and sodium benzoate (NaBz) for hyperammonemia. Sequential hemodialysis (HD) then hemofiltration (HF) was performed due to hyperammonemia. Dialytic and convective clearance (K; ml/min) of ammonia, NaPh, and NaBz was measured. The K of ammonia was 57 and 37 for HD and HF, respectively. The K of NaBz was 37 and 12 for HD and HF, respectively. The K of NaPh was 38 and 14 ml/min for HD and HF, respectively. Despite high clearance of both NaPh and NaBz by HD and HF, the hyperammonemia was corrected.
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Base de dados:
MEDLINE
Assunto principal:
Fenilacetatos
/
Diálise Renal
/
Hemofiltração
/
Benzoato de Sódio
/
Hiperamonemia
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article