Acid-catalyzed synthesis of oxathiolone fused chalcones. Comparison of their activity toward various microorganisms and human cancer cells line.
Eur J Med Chem
; 42(5): 729-33, 2007 May.
Article
em En
| MEDLINE
| ID: mdl-17300856
ABSTRACT
Substituted oxathiolone fused chalcones were prepared by condensation of 4-acetyl-5-methoxy-2-oxo-benz[1,3]oxathiole with benzaldehydes under acidic conditions. The compounds were tested for cytotoxic, antibacterial, antifungal and tuberculostatic activity. Three derivatives demonstrated weak activity against HeLa cells, two were slightly active against Micrococcus luteus and Staphylococcus aureus, and one was active against Mycobacterium tuberculosis H(37)Rv.
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Base de dados:
MEDLINE
Assunto principal:
Tionas
/
Ácidos
/
Chalconas
/
Antibacterianos
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article