Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression.
Br J Cancer
; 96(5): 758-61, 2007 Mar 12.
Article
em En
| MEDLINE
| ID: mdl-17311022
ABSTRACT
The potential utility of tumour-selective 5-fluorouracil treatment using attenuated Salmonella serovar typhimurium recombinant for cytosine deaminase (TAPET-CD) has been documented in experimental settings. The present data demonstrate that in vivo (19)F-magnetic resonance spectroscopy measurements allow the outcome prediction of this prokaryotic-based therapy, demonstrating the necessity of non-invasive real-time imaging techniques for treatment monitoring.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
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Citosina Desaminase
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Flucitosina
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Fluoruracila
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Neoplasias Experimentais
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Antineoplásicos
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article