Th1 and Th2 cells help CD8 T-cell responses.
Infect Immun
; 75(5): 2291-6, 2007 May.
Article
em En
| MEDLINE
| ID: mdl-17325050
ABSTRACT
Help from CD4 T cells is often important for the establishment of primary and memory CD8 T-cell responses. However, it has yet to be determined whether T helper polarization affects the delivery of help and/or whether responding CD8 T cells helped by Th1 or Th2 cells express distinct effector properties. To address these issues, we compared CD8 T-cell responses in the context of Th1 or Th2 help by injecting dendritic cells copulsed with the major histocompatibility complex class I-restricted OVA peptide plus, respectively, bacterial or helminth antigens. We found that Th2 cells, like Th1 cells, can help primary and long-lived memory CD8 T-cell responses. Experiments in interleukin-12 (IL-12)-/- and IL-4-/- mice, in which polarized Th1 or Th2 responses, respectively, fail to develop, indicate that the underlying basis of CD4 help is independent of attributes acquired as a response to polarization.
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Base de dados:
MEDLINE
Assunto principal:
Ativação Linfocitária
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Células Th2
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Células Th1
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Linfócitos T CD8-Positivos
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Memória Imunológica
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article