Drug insight: aminosalicylates for the treatment of IBD.
Nat Clin Pract Gastroenterol Hepatol
; 4(3): 160-70, 2007 Mar.
Article
em En
| MEDLINE
| ID: mdl-17339853
ABSTRACT
Sulfasalazine and mesalazine (also known as mesalamine; 5-aminosalicylic acid) preparations have for many years been used for the treatment of IBD (i.e. ulcerative colitis and Crohn's disease), for both active disease and the control of remission. It has also been suggested that mesalazine is a chemoprophylactic agent that protects against the development of colorectal cancer. This Review focuses on the latest clinical evidence for the use of these aminosalicylates for the treatment of IBD, and concludes that sulfasalazine and mesalazine are useful for the treatment of both active and quiescent ulcerative colitis, whereas they have no clinical effect on either active or inactive Crohn's disease. Furthermore, evidence is lacking that mesalazine per se is a chemoprophylactic agent.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Doenças Inflamatórias Intestinais
/
Anti-Inflamatórios não Esteroides
/
Ácidos Aminossalicílicos
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article