In vitro activity against anaerobes of retapamulin, a new topical antibiotic for treatment of skin infections.
J Antimicrob Chemother
; 59(4): 646-51, 2007 Apr.
Article
em En
| MEDLINE
| ID: mdl-17350985
ABSTRACT
OBJECTIVES:
Retapamulin is the first agent of the pleuromutilin class formulated as a topical antibacterial for treating skin infections. The aim of this study was to determine the antimicrobial activity of retapamulin by determining the minimal inhibitory concentration (MIC) values of this new drug and comparators against a wide range of anaerobic bacteria of human origin.METHODS:
The in vitro activity of retapamulin and six comparators (amoxicillin, amoxicillin/clavulanic acid, ceftriaxone, imipenem, clindamycin and metronidazole) was evaluated against 232 anaerobic clinical isolates. MICs were determined by the CLSI reference agar dilution method (M11-A6).RESULTS:
Ceftriaxone, clindamycin and amoxicillin/clavulanic acid resistance rates were 54%, 42% and 9.6%, respectively, within the Bacteroides fragilis group. Despite high resistance rates to various antibiotics, retapamulin inhibited 37/52 (71%) strains of the B. fragilis group and 85/87 (98%) of the other Gram-negative bacilli at a concentration of 2 mg/L or less. All the investigated strains of Clostridium perfringens were inhibited by 1 mg/L retapamulin. Three strains of C. difficile and one strain of C. clostridioforme demonstrated decreased susceptibility to retapamulin. Based on inhibitory concentrations, retapamulin was more active than clindamycin, metronidazole and ceftriaxone against Propionibacterium acnes and anaerobic Gram-positive cocci, as all isolates were inhibited by
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Base de dados:
MEDLINE
Assunto principal:
Dermatopatias Infecciosas
/
Bactérias Anaeróbias
/
Compostos Bicíclicos Heterocíclicos com Pontes
/
Anti-Infecciosos Locais
/
Antibacterianos
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article