House dust mite allergen avoidance and self-management in allergic patients with asthma: randomised controlled trial.
Br J Gen Pract
; 57(536): 184-90, 2007 Mar.
Article
em En
| MEDLINE
| ID: mdl-17359604
ABSTRACT
BACKGROUND:
The efficacy of bed covers that are impermeable to house dust mites has been disputed.AIM:
The aim of the present study was to investigate whether the combination of 'house dust mite impermeable' covers and a self-management plan, based on peak flow values and symptoms, leads to reduced use of inhaled corticosteroids (ICS) than self-management alone. DESIGN OF STUDY Prospective, randomised, double blind, placebo-controlled trial.SETTING:
Primary care in a south-eastern region of the Netherlands.METHOD:
Asthma patients aged between 16 and 60 years with a house dust mite allergy requiring ICS were randomised to intervention and placebo groups. They were trained to use a self-management plan based on peak flow and symptoms. After a 3-month training period, the intervention commenced using house dust mite impermeable and placebo bed covers. The follow-up period was 2 years. Primary outcome was the use of ICS; secondary outcomes were peak expiratory flow parameters, asthma control, and symptoms.RESULTS:
One hundred and twenty-six patients started the intervention with house dust mite impermeable or placebo bed covers. After 1 and 2 years, significant differences in allergen exposure were found between the intervention and control groups (P<0.001). No significant difference between the intervention and control groups was found in the dose of ICS (P = 0.08), morning peak flow (P = 0.52), peak flow variability (P = 0.36), dyspnoea (P = 0.46), wheezing (P = 0.77), or coughing (P = 0.41). There was no difference in asthma control between the intervention and control groups.CONCLUSION:
House dust mite impermeable bed covers combined with self-management do not lead to reduced use of ICS compared with self-management alone.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Asma
/
Controle de Ácaros e Carrapatos
/
Corticosteroides
/
Pyroglyphidae
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article