Electrostatic ligand coatings of nanoparticles enable ligand-specific gene delivery to human primary cells.
Nano Lett
; 7(4): 874-9, 2007 Apr.
Article
em En
| MEDLINE
| ID: mdl-17362046
ABSTRACT
A general method of coating polymer/DNA nanoparticles was developed. Peptide coated nanoparticles were found to have favorable biophysical characteristics including small particle size, near-neutral zeta potential, and stability in serum. At appropriate formulation conditions including near-neutral charge ratio, the coated nanoparticles enabled effective ligand-specific gene delivery to human primary endothelial cells in serum-containing media. As this nanoparticulate drug delivery system has high efficacy, ligand-based specificity, biodegradability, and low cytotoxicity, it may be potentially useful in several clinical applications.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
DNA
/
Transfecção
/
Sistemas de Liberação de Medicamentos
/
Técnicas de Transferência de Genes
/
Células Endoteliais
/
Nanopartículas
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article