Down-regulation of zeta chain and zeta-associated protein 70 (Zap 70) expression in circulating T lymphocytes in laryngeal squamous cell carcinoma.
Anal Quant Cytol Histol
; 29(1): 57-62, 2007 Feb.
Article
em En
| MEDLINE
| ID: mdl-17375875
ABSTRACT
OBJECTIVE:
To evaluate zeta chain and Zap 70 expression in T lymphocytes of patients with laryngeal cancer in relation to surgical treatment. STUDYDESIGN:
This study investigated, by dual-color flow cytometry, zeta chain and Zap 70 expression in the circulating T lymphocytes of 13 patients with laryngeal cancer patients before and after surgical treatment.RESULTS:
Patients exhibited a significant lower expression of both zeta chain and Zap 70 compared to healthy normal controls; no statistical differences were observed after surgical treatment.CONCLUSION:
The results of this investigation seem to indicate that both the zeta chain and the Zap 70 expression in circulating T lymphocytes are down-regulated in patients with laryngeal cancer and that these changes do not immediately return to normal after surgery. Flow cytometry analysis may represent an easy-to-use procedure for monitoring the immune status of patients with laryngeal cancer.
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Escamosas
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Receptores de Antígenos de Linfócitos T
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Linfócitos T
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Neoplasias Laríngeas
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Proteína-Tirosina Quinase ZAP-70
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Proteínas de Membrana
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article