The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression.
FEBS Lett
; 581(8): 1617-24, 2007 Apr 17.
Article
em En
| MEDLINE
| ID: mdl-17391671
ABSTRACT
Plakophilin 3 (PKP3) belongs to the p120ctn family of armadillo-related proteins predominantly functioning in desmosome formation. Here we report that PKP3 is transcriptionally repressed by the E-cadherin repressor ZEB1 in metastatic cancer cells. ZEB1 physically associates with two conserved E-box elements in the PKP3 promoter and partially represses the activity of corresponding human and mouse PKP3 promoter fragments in reporter gene assays. In human tumours ZEB1 is upregulated in invasive cancer cells at the tumour-host interface, which is accompanied by downregulation of PKP3 expression levels. Hence, the transcriptional repression of PKP3 by ZEB1 contributes to ZEB1-mediated disintegration of intercellular adhesion and epithelial to mesenchymal transition.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
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Fatores de Transcrição
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Regulação Neoplásica da Expressão Gênica
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Proteínas de Homeodomínio
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Placofilinas
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Neoplasias
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article