Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam--probes of CYP2C9, CYP1A2, and CYP3A4.
Clin Pharmacol Ther
; 81(6): 833-9, 2007 Jun.
Article
em En
| MEDLINE
| ID: mdl-17392729
ABSTRACT
Case reports suggest that cranberry juice can increase the anticoagulant effect of warfarin. We investigated the effects of cranberry juice on R-S-warfarin, tizanidine, and midazolam; probes of CYP2C9, CYP1A2, and CYP3A4. Ten healthy volunteers took 200 ml cranberry juice or water t.i.d. for 10 days. On day 5, they ingested 10 mg racemic R-S-warfarin, 1 mg tizanidine, and 0.5 mg midazolam, with juice or water, followed by monitoring of drug concentrations and thromboplastin time. Cranberry juice did not increase the peak plasma concentration or area under concentration-time curve (AUC) of the probe drugs or their metabolites, but slightly decreased (7%; P=0.051) the AUC of S-warfarin. Cranberry juice did not change the anticoagulant effect of warfarin. Daily ingestion of cranberry juice does not inhibit the activities of CYP2C9, CYP1A2, or CYP3A4. A pharmacokinetic mechanism for the cranberry juice-warfarin interaction seems unlikely.
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Base de dados:
MEDLINE
Assunto principal:
Varfarina
/
Bebidas
/
Midazolam
/
Hidrocarboneto de Aril Hidroxilases
/
Clonidina
/
Interações Alimento-Droga
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Citocromo P-450 CYP1A2
/
Vaccinium macrocarpon
/
Sistema Enzimático do Citocromo P-450
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article