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Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs.
Veerman, Krystle M; Williams, Michael J; Uchimura, Kenji; Singer, Mark S; Merzaban, Jasmeen S; Naus, Silvia; Carlow, Douglas A; Owen, Philip; Rivera-Nieves, Jesús; Rosen, Steven D; Ziltener, Hermann J.
Afiliação
  • Veerman KM; The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Nat Immunol ; 8(5): 532-9, 2007 May.
Article em En | MEDLINE | ID: mdl-17401367
P-selectin glycoprotein ligand 1 (PSGL-1) is central to the trafficking of immune effector cells to areas of inflammation through direct interactions with P-selectin, E-selectin and L-selectin. Here we show that PSGL-1 was also required for efficient homing of resting T cells to secondary lymphoid organs but functioned independently of selectin binding. PSGL-1 mediated an enhanced chemotactic T cell response to the secondary lymphoid organ chemokines CCL21 and CCL19 but not to CXCL12 or to inflammatory chemokines. Our data show involvement of PSGL-1 in facilitating the entry of T cells into secondary lymphoid organs, thereby demonstrating the bifunctional nature of this molecule.
Assuntos
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Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Linfócitos T / Quimiocinas CC / Homeostase / Tecido Linfoide Idioma: En Ano de publicação: 2007 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Linfócitos T / Quimiocinas CC / Homeostase / Tecido Linfoide Idioma: En Ano de publicação: 2007 Tipo de documento: Article