Susceptibility of Pseudomonas aeruginosa to antimicrobials: a 2004 French multicentre hospital study.
J Antimicrob Chemother
; 59(5): 1021-4, 2007 May.
Article
em En
| MEDLINE
| ID: mdl-17412726
ABSTRACT
OBJECTIVES:
Pseudomonas aeruginosa is a major causative agent of hospital infections. The purpose of this study was to determine the antibiotic susceptibility of P. aeruginosa in a French multicentre study and to investigate the mechanisms of beta-lactam resistance.METHODS:
Four hundred and fifty non-repetitive strains of P. aeruginosa were collected in 15 French university hospitals in 2004. MICs of antibiotics were measured by agar dilution methods. For all the strains with MICs of ticarcillin >16 mg/L, detection and identification of the beta-lactamases, quantitative determination of cephalosporinase and overproduction of the MexAB-OprM efflux pump were evaluated.RESULTS:
The percentages of susceptible isolates were as follows ticarcillin, 62%; ticarcillin + clavulanic acid, 61%; piperacillin, 78%; piperacillin + tazobactam, 80% (MICsCONCLUSIONS:
In the last decade, the overall susceptibility of P. aeruginosa hospital isolates to antibiotics has remained quite stable in France. However, the emergence of extended-spectrum beta-lactamases and carbapenemases in different locations is a matter of concern.
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Base de dados:
MEDLINE
Assunto principal:
Pseudomonas aeruginosa
/
Resistência beta-Lactâmica
/
Beta-Lactamas
/
Antibacterianos
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article