Conserved amino acid residues in ribosome-inactivating proteins from plants.
Biochimie
; 73(7-8): 1157-61, 1991.
Article
em En
| MEDLINE
| ID: mdl-1742358
ABSTRACT
The amino acid sequences of eleven RIPs sequenced to date have been compared in the expectation that this would be useful in the location of functionally and/or structurally important sites of these molecules. In addition to several highly conserved hydrophobic amino acids, thirteen absolutely conserved residues have been found in ricin A-chain Tyr21, Phe24, Arg29, Tyr80, Tyr123, Gly140, Ala165, Glu177, Ala178, Arg180, Glu208, Asn209 and Trp211. The role of these residues as well as of the C-terminal region have been discussed based on the results of chemical and enzymatic modifications, site-directed mutagenesis, and deletion studies.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Plantas
/
Ribossomos
/
Imunotoxinas
/
Lectinas de Plantas
/
N-Glicosil Hidrolases
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article