[Clinical study of double filtration plasmapheresis for treatment of refractory myasthenia gravis].
Nan Fang Yi Ke Da Xue Xue Bao
; 27(3): 355-7, 2007 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-17425991
ABSTRACT
OBJECTIVE:
To assess the therapeutic effect, timing of administration, complication prevention and management of the double filtration plasmapheresis (DFP) in the treatment of refractory myasthenia gravis (MG).METHODS:
Thirty-one patients with refractory MG were treated with KM 8800 membrane plasmapheresis monitor. DFP was performed every 3 days and the exchanging liquid was composed of 50 ml of 20% albumen and 1000 ml plasma substitute. Physical examination for absolute clinical score and blood sample was collected for AchR-Ab determination early in the morning on days 0, 3, 7, 14 of DFP.RESULTS:
With a total effective rate of 91.9%, complete recovery, basic recovery, improvement, and response was achieved in 2, 4, 11, and 17 patients, respectively, whereas the other 3 failed to respond. Hypotension occurred twice in 2 cases and was corrected after symptomatic treatment.CONCLUSION:
DFP may effectively lower blood AchR-Ab level of with minimal complications, and can be valuable for treatment of refractory MG.
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Base de dados:
MEDLINE
Assunto principal:
Troca Plasmática
/
Miastenia Gravis
Idioma:
Zh
Ano de publicação:
2007
Tipo de documento:
Article