Nephrotic syndrome as a clinical manifestation of systemic sclerosis.
Rheumatol Int
; 27(11): 1087-9, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17429639
ABSTRACT
We have described the unusual case of coexistence of membranous nephropathy resulting in nephrotic syndrome with systemic sclerosis. A 60-year-old patient was admitted to the Department of Nephrology with marked proteinuria and oedema. The renal biopsy specimen disclosed the features characteristic of membranous glomerulonephritis. The patient was treated with chlorambucil for 1 month followed by prednisone for 1 month. However, her condition still did not improve. Therefore, the other causes of nephrotic syndrome were investigated. Once anti-Scl-70 antibody was detected the patient was transferred to the Department of Rheumatology and Connective Tissue Diseases. Physical examination revealed Raynaud phenomenon, sclerodactylia, thickened skin of the chest and back. The patient was diagnosed with diffuse systemic sclerosis. The cyclophosphamide therapy was instituted and the patient's condition improved.
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Base de dados:
MEDLINE
Assunto principal:
Escleroderma Sistêmico
/
Glomerulonefrite Membranosa
/
Síndrome Nefrótica
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article