[Prader-Willi syndrome: metabolic aspects related to growth hormone treatment]. / Síndrome de Prader-Willi: aspectos metabólicos associados ao tratamento com hormônio de crescimento.
Arq Bras Endocrinol Metabol
; 51(1): 92-8, 2007 Feb.
Article
em Pt
| MEDLINE
| ID: mdl-17435861
ABSTRACT
AIM:
The focus of this study was to evaluate the metabolic profile of Prader-Willi Syndrome (PWS) patients treated with growth hormone. PATIENTS ANDMETHODS:
Seven patients (four boys and three girls) with ages between six years and six months and 14 years and 11 months were treated with GH 0.1 U/kg/day subcutaneous by six times a week, for two years. Anthropometric data, lipids, glucose, IGF-I and body composition were evaluated at baseline and after 12 and 24 months.RESULTS:
IGF-I levels increased in all cases. Skin folds decreased. The mean reduction in body fat was 5.0% and the mean increased in lean mass was 7.6 kg in the prepubertal patients. The pubescent girl increased 4.8 kg and showed a 5.6% decrease in fat mass. A mean gain in the bone mass was 0.07 g/cm(2) (7.3%) in prepubescent cases, and 0.02 g/cm(2) (2.0%) in the pubescent girl.CONCLUSION:
In our study GH treatment improved lean body and bone masses and had beneficial effect on lipid values.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome de Prader-Willi
/
Composição Corporal
/
Hormônio do Crescimento Humano
/
Metabolismo dos Lipídeos
Idioma:
Pt
Ano de publicação:
2007
Tipo de documento:
Article