Mitochondrial targeting of quinones: therapeutic implications.
Mitochondrion
; 7 Suppl: S94-102, 2007 Jun.
Article
em En
| MEDLINE
| ID: mdl-17449335
ABSTRACT
Mitochondrial oxidative damage contributes to a range of degenerative diseases. Ubiquinones have been shown to protect mitochondria from oxidative damage, but only a small proportion of externally administered ubiquinone is taken up by mitochondria. Conjugation of the lipophilic triphenylphosphonium cation to a ubiquinone moiety has produced a compound, MitoQ, which accumulates selectively into mitochondria. MitoQ passes easily through all biological membranes and, because of its positive charge, is accumulated several hundred-fold within mitochondria driven by the mitochondrial membrane potential. MitoQ protects mitochondria against oxidative damage in vitro and following oral delivery, and may therefore form the basis for mitochondria-protective therapies.
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Base de dados:
MEDLINE
Assunto principal:
Compostos Organofosforados
/
Quinonas
/
Ubiquinona
/
Mitocôndrias
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article