Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain.
J Neurosci
; 27(18): 4902-9, 2007 May 02.
Article
em En
| MEDLINE
| ID: mdl-17475798
ABSTRACT
Distinct types of relay neurons in the hindbrain process somatosensory or viscerosensory information. How neurons choose between these two fates is unclear. We show here that the homeobox gene Lbx1 is essential for imposing a somatosensory fate on relay neurons in the hindbrain. In Lbx1 mutant mice, viscerosensory relay neurons are specified at the expense of somatosensory relay neurons. Thus Lbx1 expression distinguishes between the somatosensory or viscerosensory fate of relay neurons.
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Base de dados:
MEDLINE
Assunto principal:
Rombencéfalo
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Fibras Aferentes Viscerais
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Proteínas Musculares
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Neurônios Aferentes
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article