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2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists.
Sandham, David A; Aldcroft, Clive; Baettig, Urs; Barker, Lucy; Beer, David; Bhalay, Gurdip; Brown, Zarin; Dubois, Gerald; Budd, David; Bidlake, Louise; Campbell, Emma; Cox, Brian; Everatt, Brian; Harrison, David; Leblanc, Catherine J; Manini, Jodie; Profit, Rachael; Stringer, Rowan; Thompson, Katy S; Turner, Katharine L; Tweed, Morris F; Walker, Christoph; Watson, Simon J; Whitebread, Steven; Willis, Jennifer; Williams, Gareth; Wilson, Caroline.
Afiliação
  • Sandham DA; Global Discovery Chemistry, Novartis Institutes of Biomedical Research, Horsham Research Centre, Wimblehurst Road, Horsham, West Sussex RH12 5AB, UK. david.sandham@novartis.com
Bioorg Med Chem Lett ; 17(15): 4347-50, 2007 Aug 01.
Article em En | MEDLINE | ID: mdl-17531480
ABSTRACT
High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavailability in the rat.
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Base de dados: MEDLINE Assunto principal: Receptores de Prostaglandina / Receptores Imunológicos / Acetatos Idioma: En Ano de publicação: 2007 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Receptores de Prostaglandina / Receptores Imunológicos / Acetatos Idioma: En Ano de publicação: 2007 Tipo de documento: Article