Expression of PD-L1, a marker of disease status, is not reduced by HAART in aviraemic patients.
AIDS
; 21(10): 1379-81, 2007 Jun 19.
Article
em En
| MEDLINE
| ID: mdl-17545722
ABSTRACT
Anergy and defective immune responses are characteristic of chronic HIV-1 infection. The programmed death 1 (PD-1)/PD-1 ligand (PD-L1) pathway appears to be involved in downregulating T-cell functionality. We found raised levels of PD-L1 in aviraemic chronically infected HIV-1-positive patients, which may contribute to incomplete immune reconstitution after treatment with HAART.
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Base de dados:
MEDLINE
Assunto principal:
Antígenos CD
/
Infecções por HIV
/
HIV-1
/
Terapia Antirretroviral de Alta Atividade
/
Proteínas Reguladoras de Apoptose
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article