Benzyl amide-ketoacid inhibitors of HIV-integrase.
Bioorg Med Chem Lett
; 17(17): 4886-90, 2007 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-17604626
ABSTRACT
Integrase is one of three enzymes expressed by HIV and represents a validated target for therapy. Previous reports have demonstrated that the diketoacid-based chemotype is a useful starting point for the design of inhibitors of this enzyme. In this study, one of the ketone groups is replaced by a benzylamide resulting in a new potent chemotype. A preliminary SAR study is carried out to investigate the substitution requirements on the phenyl ring and methylene group of the benzylamide.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores de Integrase de HIV
/
Integrase de HIV
/
Fármacos Anti-HIV
/
Amidas
/
Cetoácidos
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article