[Meta-analysis on the association of Myocilin Q368X mutation and primary open angle glaucoma].

OBJECTIVE: To study the association between Myocilin (MYOC) Gln368STOP mutation and primary open angle glaucoma (POAG) by means of Meta-analysis. METHODS: Odds ratios (OR) of MYOC Gln368STOP genotype distributions in POAG patients verse the controls were analyzed. All the relevant reported studies were identified. Poor-qualified studies were eliminated, and the risk of publication bias was excluded. Meta-analysis software, RevMan 4.2, was applied for investigating heterogeneity among individual studies and summarizing the effects across studies. RESULTS: A total of 3077 POAG cases and 2063 controls from 11 studies were included. No heterogeneity among these studies was noticed (P = 0.79). The pooled OR (with 95% CI) of MYOC Gln368STOP in POAG cases versus that in the controls was 6.01 (2.57 - 14.04, P < 0.01). CONCLUSION: MYOC Gln368STOP mutation might be associated with the increased risk of POAG and is one of its risk factors.