Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models.
Cancer Cell
; 12(1): 52-65, 2007 Jul.
Article
em En
| MEDLINE
| ID: mdl-17613436
ABSTRACT
Pancreatic cancer is an aggressive malignancy with morbidity rates almost equal to mortality rates because of the current lack of effective treatment options. Here, we describe a targeted approach to treating pancreatic cancer with effective therapeutic efficacy and safety in noninvasive imaging models. We developed a versatile expression vector "VISA" (VP16-GAL4-WPRE integrated systemic amplifier) and a CCKAR (cholecystokinin type A receptor) gene-based, pancreatic-cancer-specific promoter VISA (CCKAR-VISA) composite to target transgene expression in pancreatic tumors in vivo. Targeted expression of BikDD, a potent proapoptotic gene driven by CCKAR-VISA, exhibited significant antitumor effects on pancreatic cancer and prolonged survival in multiple xenograft and syngeneic orthotopic mouse models of pancreatic tumors with virtually no toxicity.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Modelos Biológicos
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article