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Efficacy of the human rotavirus vaccine RIX4414 in malnourished children.
Perez-Schael, Irene; Salinas, Belen; Tomat, Maria; Linhares, Alexandre C; Guerrero, M Lourdes; Ruiz-Palacios, Guillermo M; Bouckenooghe, Alain; Yarzabal, Juan Pablo.
Afiliação
  • Perez-Schael I; Instituto de Biomedicina-Fuvesin, Universidad Central de Venezuela, Ministerio de Salud, Caracas, Venezuela. ireneperezschael@cantv.net
J Infect Dis ; 196(4): 537-40, 2007 Aug 15.
Article em En | MEDLINE | ID: mdl-17624838
UNLABELLED: The effect of nutritional status on protective efficacy of a live attenuated human rotavirus vaccine (RIX4414) was studied. Vaccine protection was evaluated through a secondary analysis of data from an efficacy study conducted in Brazil, Mexico, and Venezuela. Vaccine efficacy against rotavirus gastroenteritis (RVGE) was similar in well-nourished and malnourished infants: 74.1% (95% confidence interval [CI], 52.2%-86.2%) and 73% (95% CI, 11.2%-92.3%) for severe RVGE and 60.9% (95% CI, 37.4%-75.4%) and 61.2% (95% CI, 10.4%-83.1%) for RVGE of any severity, respectively. RIX4414 significantly decreased the rate of RVGE regardless of nutritional status, which suggests that this patient group can also benefit from rotavirus vaccination. CLINICAL TRIALS REGISTRY: e-Track 444563-006, NCT00385320 (http://www.clinicaltrials.gov).
Assuntos
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Base de dados: MEDLINE Assunto principal: Infecções por Rotavirus / Vacinas Atenuadas / Vacinação / Rotavirus / Vacinas contra Rotavirus / Desnutrição Idioma: En Ano de publicação: 2007 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Infecções por Rotavirus / Vacinas Atenuadas / Vacinação / Rotavirus / Vacinas contra Rotavirus / Desnutrição Idioma: En Ano de publicação: 2007 Tipo de documento: Article