JAM-C regulates unidirectional monocyte transendothelial migration in inflammation.
Blood
; 110(7): 2545-55, 2007 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-17625065
ABSTRACT
Monocyte recruitment from the vasculature involves sequential engagement of multiple receptors, culminating in transendothelial migration and extravasation. Junctional adhesion molecule-C (JAM-C) is localized at endothelial intercellular junctions and plays a role in monocyte transmigration. Here, we show that blockade of JAM-B/-C interaction reduced monocyte numbers in the extravascular compartment through increased reverse transmigration rather than by reduced transmigration. This was confirmed in vivo, showing that an anti-JAM-C antibody reduced the number of monocytes in inflammatory tissue and increased the number of monocytes with a reverse-transmigratory phenotype in the peripheral blood. All together, our results suggest a novel mechanism of reducing accumulation of monocytes at inflammation sites by disruption of JAM-C-mediated monocyte retention.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Monócitos
/
Moléculas de Adesão Celular
/
Movimento Celular
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article