Synthesis and optimization of novel and selective muscarinic M(3) receptor antagonists.

Kumar, Naresh; Kaur, Kirandeep; Aeron, Shelly; Dharmarajan, Sankaranarayanan; Silamkoti, Arun D V; Mehta, Anita; Gupta, Suman; Chugh, Anita; Gupta, Jang B; Salman, Mohammad; Palle, Venkata P; Cliffe, Ian A

Kumar, Naresh; Kaur, Kirandeep; Aeron, Shelly; Dharmarajan, Sankaranarayanan; Silamkoti, Arun D V; Mehta, Anita; Gupta, Suman; Chugh, Anita; Gupta, Jang B; Salman, Mohammad; Palle, Venkata P; Cliffe, Ian A.

Afiliação

Kumar N; Ranbaxy Research Laboratories, New Drug Discovery Research, Department of Medicinal Chemistry, Gurgaon, Haryana 122 001, India. n.kumar@ranbaxy.com

Bioorg Med Chem Lett ; 17(18): 5256-60, 2007 Sep 15.

Article em En | MEDLINE | ID: mdl-17629699

ABSTRACT

ABSTRACT

A series of constrained piperidine analogues were synthesized as novel muscarinic M(3) receptor antagonists. Evaluation of these compounds in binding assays revealed that they not only have high affinity for the M(3) receptor but also have high selectivity over the M(2) receptor.

Assuntos

Antagonistas Muscarínicos/síntese química; Antagonistas Muscarínicos/farmacologia; Receptor Muscarínico M3/antagonistas & inibidores; Antagonistas Muscarínicos/química; Relação Estrutura-Atividade

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Base de dados: MEDLINE Assunto principal: Antagonistas Muscarínicos / Receptor Muscarínico M3 Idioma: En Ano de publicação: 2007 Tipo de documento: Article

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Imprimir

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PubMed Links

Base de dados: MEDLINE Assunto principal: Antagonistas Muscarínicos / Receptor Muscarínico M3 Idioma: En Ano de publicação: 2007 Tipo de documento: Article