Synthesis and optimization of novel and selective muscarinic M(3) receptor antagonists.
Bioorg Med Chem Lett
; 17(18): 5256-60, 2007 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-17629699
ABSTRACT
A series of constrained piperidine analogues were synthesized as novel muscarinic M(3) receptor antagonists. Evaluation of these compounds in binding assays revealed that they not only have high affinity for the M(3) receptor but also have high selectivity over the M(2) receptor.
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Base de dados:
MEDLINE
Assunto principal:
Antagonistas Muscarínicos
/
Receptor Muscarínico M3
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article