Polarization of B effector cells in Sjögren's syndrome.
Autoimmun Rev
; 6(7): 427-31, 2007 Aug.
Article
em En
| MEDLINE
| ID: mdl-17643928
ABSTRACT
Analysis of salivary glands of patients with primary Sjögren's syndrome has yielded conflicting results with respect to T helper (Th)1/Th2 polarization. This balance might parallel the progress of the local lesions. B-cells are now taking center stage in this disease. They can also be primed to differentiate into two cytokine-production pathways, dubbed B effector (Be) 1 and Be2 cells. This is discussed in the light of our recent finding that Be1 accompany Th1, while Be2 accompany in the tissue lesions.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Síndrome de Sjogren
/
Autoimunidade
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article