[Application of all-trans retinoic acid combining chemotherapy and As4S4 in the maintenance treatment of patients with acute promyelocytic leukemia].
Zhonghua Xue Ye Xue Za Zhi
; 28(1): 19-21, 2007 Jan.
Article
em Zh
| MEDLINE
| ID: mdl-17649720
ABSTRACT
OBJECTIVE:
To compare the efficacy of all-trans retinoic acid (ATRA) combining chemotherapy and As4S4 with ATRA combining chemotherapy for the maintenance treatment of patients with acute promyelocytic leukemia (APL).METHODS:
Sixty patients with APL induced to complete remission by ATRA and consolidated by chemotherapy were randomly divided into two groups. Thirty patients as As4S4 group received ATRA + As4S4 + chemotherapy, and another thirty patients as non-As4S4 group were treated only with ATRA + chemotherapy as maintenance therapy. The therapeutic effects, side effects and PML-RARalpha gene expression were analyzed.RESULTS:
The three-year continuous complete remission (CCR) rate was 90.0% for As4S4 group and 61.1% for non-As4S4 group, the difference being statistically significant. Significant difference was also found in the positive rate of PML-RARalpha fusion gene between the two groups. The side effects were mild.CONCLUSION:
APL patients in maintenance therapy with ATRA + 6-MP + MTX + As4S4 can obtain a higher CCR.
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Base de dados:
MEDLINE
Assunto principal:
Leucemia Promielocítica Aguda
/
Protocolos de Quimioterapia Combinada Antineoplásica
Idioma:
Zh
Ano de publicação:
2007
Tipo de documento:
Article