Neuronal NF-kappaB influences thermoregulation and survival in a sepsis model.
J Neuroimmunol
; 189(1-2): 41-9, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17655939
ABSTRACT
Gene regulation in sepsis is known to be controlled by the transcription factor NF-kappaB. However, the function of neuronal NF-kappaB in sepsis is not well defined. In a mouse model of sepsis induced by i.p. injection of lipopolysaccharides (LPS), we found an activation of NF-kappaB in the brain as shown by the induction of a transgenic NF-kappaB reporter. Inhibition of neuronal NF-kappaB by cell-specific expression of the NF-kappaB super-repressor IkappaBalpha-SR improved LPS-induced hypothermia and survival but had no effect on body weight or on the humoral response to LPS. In contrast, glial inhibition of NF-kappaB did not influence body temperature and survival. By immunohistochemistry, we detected the active NF-kappaB subunit RelA in neuronal nuclei of the organum vasculosum of the lamina terminalis. Our data reveal an important role of neuronal NF-kappaB in thermoregulation and survival. The upcoming group of NF-kappaB inhibitors may have a place in the treatment of the acute-phase response.
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Base de dados:
MEDLINE
Assunto principal:
NF-kappa B
/
Sepse
/
Inibição Neural
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article