Neuronal networks of the basal ganglia and the value of recording field potentials from them.

ABSTRACT

The basal ganglia constitute parts of highly sophisticated and complex neuronal networks, which represent essential elements of functional circuits, actively involved in the control of movement. The physiologic properties of these networks and their interchange with different brain areas could serve as a model for the pathophysiologic explanation of various movement disorders, particularly Parkinson's disease. Stimulation of these networks and subsequent recording of the evoked Local Field Potentials is currently used not only for understanding the pathophysiology of movement disorders but also for the physiologic localization of the anatomical target during deep brain stimulation procedures. An overview of the currently available research and clinical data from the recording of Local Field Potentials as well as the advantages, the disadvantages and the limitations of this methodology are presented in this chapter.