Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation.
Oncogene
; 27(8): 1063-70, 2008 Feb 14.
Article
em En
| MEDLINE
| ID: mdl-17700526
ABSTRACT
Stromal-epithelial interactions play a central role in development and tumorigenesis. Bone morphogenetic protein (BMP) signaling in the intestine is involved in both of these processes. Inactivation of BMP pathway genes in the epithelium is known to cause intestinal polyposis. However, the role of the intestinal stroma in polyp initiation is incompletely understood. We observed that conditional inactivation of the BMP type II receptor (BMPRII) in the stroma leads to epithelial hyperplasia throughout the colon with increased epithelial cell proliferation. Mutant mice developed rectal bleeding and hamartomatous polyps in the colorectum. The polyps demonstrated increased proliferation of epithelial and mesenchymal cells in the mucosa with an expansion of the myofibroblast cell population. These results demonstrate that genetic mutations altering the BMP signaling pathway in the stromal microenvironment can lead to epithelial tumors in the colon.
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Base de dados:
MEDLINE
Assunto principal:
Reto
/
Comunicação Celular
/
Pólipos do Colo
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Proteínas Morfogenéticas Ósseas
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Proliferação de Células
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Receptores de Proteínas Morfogenéticas Ósseas Tipo II
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Mucosa Intestinal
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article