Multi-drug resistance mediated by P-glycoprotein overexpression is not correlated with ZAP-70/CD38 expression in B-cell chronic lymphocytic leukemia.
Leuk Lymphoma
; 48(8): 1556-60, 2007 Aug.
Article
em En
| MEDLINE
| ID: mdl-17701587
ABSTRACT
ZAP-70 and CD38 expression can identify B-cell chronic lymphocytic leukemia with an inferior clinical outcome. Many groups have investigated the meaning of the expression of these two proteins and the correlation with the bad prognosis in B-CLL. But nobody has investigated the relation between the multidrug resistance mediated by Pgp overexpression (MDR1) and ZAP-70/CD38 coexpression. Forty-one untreated and stage A patients, either ZAP-70(+)CD38(+) or ZAP-70(-)CD38(-), were tested to determine the MDR1 status. MDR1 was observed in 41% of CLL ZAP-70(+)CD38(+) and in 37% of CLL ZAP-70(-)CD38(-). The difference was not significant (p = 0.745). Patients with ZAP-70 and CD38 positive CLL can not be candidates for MDR1 antagonists.
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Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
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Leucemia Linfocítica Crônica de Células B
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Regulação Leucêmica da Expressão Gênica
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Membro 1 da Subfamília B de Cassetes de Ligação de ATP
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Resistência a Múltiplos Medicamentos
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ADP-Ribosil Ciclase 1
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Proteína-Tirosina Quinase ZAP-70
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article