A high-power laser-driven source of sub-nanosecond soft X-ray pulses for single-shot radiobiology experiments.
Radiat Res
; 168(3): 382-7, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17705629
ABSTRACT
A large-scale, double-stream gas puff target has been illuminated by sub-kJ, near-infrared (NIR) focused laser pulses at the PALS facility (Prague Asterix Laser System) to produce high-energy pulses of soft X rays from hot, dense plasma. The double-puff arrangement ensures high gas density and conversion efficiency from NIR to X rays approaching that typical for solid targets. In addition, its major advantage over solid targets is that it is free of debris and has substantially suppressed charged-particle emission. The X-ray emission characteristics of the source were determined for a range of gases that included krypton, xenon, N(2), CO and N(2)-CO. A demonstrated application of the xenon-based source is a single-shot damage induction to plasmid DNA. The yields of single-strand breaks (SSBs) and double-strand breaks (DSBs) were determined as a function of energy fluence adjusted by varying distance of sample from the source and thickness of aluminum filters.
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Base de dados:
MEDLINE
Assunto principal:
Plasmídeos
/
Radiobiologia
/
Pesquisa
/
Manejo de Espécimes
/
Raios X
/
Dano ao DNA
/
Lasers
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article