Association of n-6 long-chain polyunsaturated fatty acids to -866 G/A genotypes of the human uncoupling protein 2 gene in obese children.
Acta Paediatr
; 96(9): 1350-4, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17718790
ABSTRACT
AIM:
To investigate the association of plasma fatty acids with the -866 G/A polymorphism of uncoupling protein 2 (UCP2) in obese children.METHODS:
Fatty acid composition of plasma phospholipids and sterol esters were investigated in 80 obese children.RESULTS:
Values of dihomo-gamma-linolenic acid (C203n-6) were significantly lower in children with the -866 A/A (n = 12) than in those with the -866 G/A (n = 34) or -866 G/G (n = 34) genotype in plasma phospholipids (3.01 [0.42] vs. 3.56 [1.02] vs. 3.53 [0.84], % weight/weight, median [interquartile range], p < 0.05), and were significantly lower in children with the -866 A/A genotype than in the other two groups in plasma sterol esters (0.73 [0.22] vs. 0.92 [0.23] vs. 0.94 [0.25], p < 0.05). Phospholipid C203n-6 and arachidonic acid (C204n-6) values showed only in children with the -866 G/G and -866 G/A genotypes significant positive correlations with plasma insulin concentrations.CONCLUSIONS:
Significantly lower values of C203n-6 can be detected in obese children with the homozygous (-866 A/A) mutation of UCP2 than in equally obese children with heterozygous mutation or the normal genotype. High glucose-stimulated insulin response is associated with high plasma C203n-6 and C204n-6 values only in obese children with the G allele of the -866 G/A polymorphism.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Mitocondriais
/
Ácidos Graxos Ômega-6
/
Ácidos Graxos Insaturados
/
Genótipo
/
Canais Iônicos
/
Obesidade
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article