Recurrence of peptic ulcer in uraemic and non-uraemic patients after Helicobacter pylori eradication: a 2-year study.
Aliment Pharmacol Ther
; 26(6): 925-33, 2007 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-17767477
ABSTRACT
BACKGROUND:
The role of Helicobacter pylori in the pathogenesis of peptic ulcer disease in patients with uraemia remains unclear.AIM:
To evaluate the long-term effect of H. pylori eradication in these patients.METHODS:
Uraemic and non-uraemic patients with peptic ulcer were enrolled in this study. Patients having history of non-steroidal anti-inflammatory drugs use or cardiovascular disease that need aspirin use were excluded. After confirmation of H. pylori infection, they received a triple therapy and were followed up for 2 years.RESULTS:
Between September 1999 and December 2005, 34 patients (41%) of the end-stage renal disease [H. pylori (+) group] and 67 (84%) of the non-uraemic patients with peptic ulcer disease (PU group) received anti-H. pylori therapy. After triple therapy, 32 (94%) from the end-stage renal disease group and 64 (96%) from the peptic ulcer group obtained successful eradication. During the 2-year follow-up, three patients in the end-stage renal disease group were excluded because of the presence of cardiovascular disease and aspirin use in two cases and died of heart failure in one case; two patients in peptic ulcer group refused follow-up. Finally, 29 uraemic and 62 non-uraemic patients had achieved the follow-up. Recurrence of peptic ulcer was more in the end-stage renal disease group than in the peptic ulcer group with intention-to-treat analysis (eight of 32, 25% vs. two of 64, 3%, P = 0.001, OR 10.0, 95% CI 1.979-50.540) or per-protocol analysis (eight of 29, 28% vs. two of 62, 3%, P < 0.001, OR 11.4, 95% CI 2.245-58.168).CONCLUSIONS:
Peptic ulcer recurrence after H. pylori eradication is higher in end-stage renal disease patients with peptic ulcer than in peptic ulcer patients without renal disease. Factors aside from H. pylori play an important role in peptic ulcer recurrence in end-stage renal disease patients.
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Base de dados:
MEDLINE
Assunto principal:
Úlcera Péptica
/
Helicobacter pylori
/
Inibidores da Bomba de Prótons
/
Antiulcerosos
/
Antibacterianos
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article