[Effect of enhancers on cutaneous permeation of piroxicam in vitro].
Zhongguo Yao Li Xue Bao
; 12(3): 235-8, 1991 May.
Article
em Zh
| MEDLINE
| ID: mdl-1781286
ABSTRACT
Enhancing effects on the permeation of piroxicam (Pir) through excised hairless mouse (inbred HRS mice) skin were investigated by measuring flux. Azone 1% was found to be the most effective enhancer studied, increasing the flux about 21 times. The effect of Azone was enhanced by the presence of propylene glycol. Oleic acid, ethylacetate, and ethanol promoted the diffusion of Pir. Other enhancers, such as DMSO, PEG 400, acetone, urea and salicylic acid, showed little or no effect. Pir-beta-cyclodextrin inclusion compound increased the flux about 3 times. The results revealed that lipophilic enhancers were more effective than lipophobic ones.
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Base de dados:
MEDLINE
Assunto principal:
Absorção Cutânea
/
Azepinas
/
Piroxicam
Idioma:
Zh
Ano de publicação:
1991
Tipo de documento:
Article