On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide-alkyne cycloaddition.
Bioorg Med Chem Lett
; 17(20): 5590-4, 2007 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-17826090
ABSTRACT
Cyclic peptides were obtained, on-resin, by the copper (I) catalysed 1,3-dipolar cycloaddition of azides and alkynes. The reaction led exclusively to the formation of the expected cyclomonomeric products which acted as ligands of the Vascular Endothelial Growth Factor receptor 1.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Azidas
/
Cobre
/
Receptor 1 de Fatores de Crescimento do Endotélio Vascular
/
Alcinos
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article