(1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production.

Hu, Lain-Yen; Du, Daniel; Hoffman, Jennifer; Smith, Yvonne; Fedij, Victor; Kostlan, Catherine; Johnson, Theodore R; Huang, Yun; Kesten, Steve; Harter, William; Yue, Wen Song; Li, Jie Jack; Barvian, Nicole; Mitchell, Lorna; Lei, Huangshu John; Lefker, Bruce; Carroll, Mathew; Dettling, Danielle; Krieger-Burke, Teresa; Samas, Brian; Yalamanchili, Radhika; Lapham, Kimberly; Pocalyko, David; Sliskovic, Drago; Ciotti, Susan; Stoller, Brenda; Hena, Mostofa A; Ding, Qizhu; Maiti, Samarendra N; Stier, Michael; Welgus, Howard

Hu, Lain-Yen; Du, Daniel; Hoffman, Jennifer; Smith, Yvonne; Fedij, Victor; Kostlan, Catherine; Johnson, Theodore R; Huang, Yun; Kesten, Steve; Harter, William; Yue, Wen Song; Li, Jie Jack; Barvian, Nicole; Mitchell, Lorna; Lei, Huangshu John; Lefker, Bruce; Carroll, Mathew; Dettling, Danielle; Krieger-Burke, Teresa; Samas, Brian; Yalamanchili, Radhika; Lapham, Kimberly; Pocalyko, David; Sliskovic, Drago; Ciotti, Susan; Stoller, Brenda; Hena, Mostofa A; Ding, Qizhu; Maiti, Samarendra N; Stier, Michael; Welgus, Howard.

Afiliação

Hu LY; Pfizer Global Research and Development, Ann Arbor Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. lain-yen.hu@pfizer.com

Bioorg Med Chem Lett ; 17(21): 5983-8, 2007 Nov 01.

Article em En | MEDLINE | ID: mdl-17827000

Assuntos

Antagonistas de Androgênios/farmacologia; Cabelo/crescimento & desenvolvimento; Hidrocarbonetos Fluorados/farmacologia; Nitrilas/farmacologia; Sebo; Animais; Cricetinae; Hidrocarbonetos Fluorados/farmacocinética; Masculino; Mesocricetus; Camundongos; Modelos Moleculares; Nitrilas/farmacocinética

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Base de dados: MEDLINE Assunto principal: Sebo / Cabelo / Hidrocarbonetos Fluorados / Antagonistas de Androgênios / Nitrilas Idioma: En Ano de publicação: 2007 Tipo de documento: Article

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