Identification of the DNA sequence interacting with Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 1.
J Virol
; 81(22): 12680-4, 2007 Nov.
Article
em En
| MEDLINE
| ID: mdl-17855527
ABSTRACT
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma. The open reading frame (K9) of KSHV encodes viral interferon regulatory factor 1 (vIRF1), which functions as a repressor of interferon-mediated signal transduction. The amino-terminal region of vIRF1 displays significant homology to the DNA-binding domain of cellular interferon regulatory factors, supporting the theory that the protein interacts with specific DNA sequences. Here, we identify the consensus sequence of vIRF1-binding sites from a pool of random oligonucleotides. Moreover, our data show that vIRF1 interacts with the K3viral dihydrofolate reductaseviral interleukin 6 promoter region in the KSHV genome.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
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Proteínas Virais
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DNA Viral
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Regulação Viral da Expressão Gênica
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Herpesvirus Humano 8
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Fatores Reguladores de Interferon
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article