[Role of AT2 receptors on angiotensin II-induced tumor necrosis factor alpha and interleukin 1 beta secretion in adult rat cardiac fibroblasts].
Nan Fang Yi Ke Da Xue Xue Bao
; 27(9): 1307-9, 2007 Sep.
Article
em Zh
| MEDLINE
| ID: mdl-17884764
ABSTRACT
OBJECTIVE:
To investigate the role of AT2 receptors in the secretion of tumor necrosis factor alpha (alpha-TNF) and interleukin 1 beta (IL1 beta) in adult rat cardiac fibroblasts.METHODS:
Adult rat cardiac fibroblasts in in vitro culture were divided into control, Ang II, AngII + Losartan, and AngII + PD123319 groups with corresponding treatments. Radioimmunoassay was used to determine alpha-TNF and IL1 beta levels in the supernatant of the treated cardiac fibroblasts.RESULTS:
Ang II treatment resulted in significantly increased alpha-TNF and IL1 beta levels. Compared with AngII group, IL1 beta level was decreased by 69.1% and 78.7% and alpha-TNF by 58.7% and 65.9% after blocking AT1 and AT2 receptors, respectively.CONCLUSION:
AT2 receptors are involved in alpha-TNF and IL1 beta secretions in cardiac fibroblasts.
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Base de dados:
MEDLINE
Assunto principal:
Angiotensina II
/
Fator de Necrose Tumoral alfa
/
Receptor Tipo 2 de Angiotensina
/
Interleucina-1beta
/
Fibroblastos
/
Miocárdio
Idioma:
Zh
Ano de publicação:
2007
Tipo de documento:
Article