The role of bowel surgery with cytoreduction for epithelial ovarian cancer.
Clin Oncol (R Coll Radiol)
; 19(10): 757-62, 2007 Dec.
Article
em En
| MEDLINE
| ID: mdl-17889517
ABSTRACT
AIMS:
To assess the efficiency and morbidity associated with bowel resection with the initial cytoreduction procedure for advanced ovarian cancer. MATERIALS ANDMETHODS:
A review was carried of 95 patients with ovarian cancer who underwent cytoreductive surgery between 2000 and 2003. The relationship between dichotomised preoperative, intra-operative and postoperative outcome variables were tested using SPSS software. Kaplan-Meier curves were generated to compare survival. Cox proportional hazards regression was used to determine the independent significance of factors after cytoreductive surgery.RESULTS:
In patients in whom bowel resection was carried out, the largest residual tumour mass was <1cm in 66.67% of patients, compared with 45.28% of patients undergoing surgery without bowel resection (P=0.038). The median survival in the optimally debulked patients was 50.38 months compared with 37.15 months in the patients who had suboptimal cytoreduction (P=0.0021). The median survival in patients undergoing bowel resection was 50.70 months compared with 44.62 months in the patients who had cytoreduction without bowel resection (P=0.2176). Multivariate analysis showed that optimal cytoreduction (P=0.005) was found to be independently prognostic for overall survival. Major adverse events, such as ileus, intestinal fistulae, urinary tract fistulae, were not significantly different between groups.CONCLUSION:
Bowel resection is a worthwhile endeavour in selected patients with advanced ovarian cancer to increase therapeutic efficiency. The surgical morbidity rate from these procedures is not serious and seems acceptable.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Procedimentos Cirúrgicos em Ginecologia
/
Colectomia
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Neoplasias Epiteliais e Glandulares
/
Neoplasia Residual
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article