Mini review on molecular modeling of P-glycoprotein (Pgp).
Curr Top Med Chem
; 7(15): 1525-9, 2007.
Article
em En
| MEDLINE
| ID: mdl-17897039
ABSTRACT
Membrane bound P-glycoprotein (Pgp) acts as an active transport pump. It plays a major role as a cause of multidrug resistance (MDR) and acts as a component of the blood-brain barrier. Pgp transports a wide variety of structurally unrelated compound from the cell interior into the extracellular space. Recent molecular modeling efforts, mostly in homology modeling and QSAR studies, have brought some understanding to the interactions between the protein and the drugs at the atomic level. We review the recent developments from the point of view of methodology.
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Base de dados:
MEDLINE
Assunto principal:
Modelos Moleculares
/
Membro 1 da Subfamília B de Cassetes de Ligação de ATP
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article