[Frequencies of GSTM1, GSTT1, and GSTP1 polymorphisms in ethnic minority from Guizhou].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 24(5): 589-91, 2007 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-17922436
ABSTRACT
OBJECTIVE:
To investigate the frequencies of GSTM1, GSTT1 and GSTP1 polymorphisms in Dong, Yi and Yao ethnic groups from Guizhou.METHODS:
In 321 volunteers who were population-based, GSTM1 and GSTT1 polymorphisms were analyzed by a multiplex-PCR procedure, whereas GSTP1 polymorphism was analyzed by PCR-RFLP method.RESULTS:
Null genotype for GSTM1 and GSTT1 was 59.6%-71.2% and 39.4%-72.5%, respectively. The genotypic distribution of GSTP1 was 63.3%-75% for AA, 23.2%-35.8% for AG, 0-1.9% for GG, whereas the allelic frequencies were 81.2%-86.6% for the A allele, and 13.4%-18.8% for the G allele.CONCLUSION:
There is a significant relationship between GSTT1 frequencies and ethnic populations.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Etnicidade
/
Frequência do Gene
/
Glutationa Transferase
Idioma:
Zh
Ano de publicação:
2007
Tipo de documento:
Article