Reduced thymic size and numbers of splenic CD4+ and CD8+ cells in artificially reared mouse pups.
Biosci Biotechnol Biochem
; 71(10): 2420-7, 2007 Oct.
Article
em En
| MEDLINE
| ID: mdl-17928720
ABSTRACT
The effect of early nutrition on the development of the immune tissue and T cells of mouse pups was examined. Newborn mice were divided into three experimental groups mother-reared (MR) pups, pups that were fed on a milk substitute from the first day (AR-0), and the third day (AR-2), using a hand-feeding system. The average thymic size of the AR-2 pups was respectively significantly larger and smaller than that of the AR-0 and MR pups. In contrast, the splenic sizes of the AR-0 and AR-2 pups were greater than that of the MR pups. The numbers of CD4+CD8- and CD4-CD8+ cells in the spleen of the MR pups were significantly higher than those in the AR-0 pups. These results indicate that early nutrition affected the sizes of the thymus and spleen and the composition of CD4+CD8- or CD4-CD8+ T cells in the spleen.
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Base de dados:
MEDLINE
Assunto principal:
Baço
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Timo
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Relação CD4-CD8
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Leite
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Fenômenos Fisiológicos da Nutrição Animal
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article