Pentoxifylline suppresses transduction by HIV-1-based vectors.
Intervirology
; 50(5): 377-86, 2007.
Article
em En
| MEDLINE
| ID: mdl-17938572
ABSTRACT
Pentoxifylline, a caffeine-related compound, was shown to suppress human immunodeficiency virus type 1 (HIV-1) replication. This effect is thought to be mediated by inhibition of tumor necrosis factor-alpha (TNFalpha)-mediated long-terminal repeat (LTR)-driven expression. We now demonstrate that pentoxifylline efficiently inhibits transduction by HIV-1-based vectors. This latter effect is independent of LTR-driven expression, and correlates with a reduced efficiency of the completion of the integration process in infected cells. Finally, the effect of pentoxifylline is dramatically reduced in cells expressing a dominant negative ATR protein, and in primary human cells that exhibit low level of ATR activity, suggesting that the effect of pentoxifylline on HIV-1 transduction and replication is at least partly mediated by suppression of the ATR kinase.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Pentoxifilina
/
Transdução Genética
/
HIV-1
/
Vetores Genéticos
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article