One-year results of the SCORPIUS study: a German multicenter investigation on the effectiveness of sirolimus-eluting stents in diabetic patients.
J Am Coll Cardiol
; 50(17): 1627-34, 2007 Oct 23.
Article
em En
| MEDLINE
| ID: mdl-17950142
ABSTRACT
OBJECTIVES:
This study sought to analyze the effectiveness of drug-eluting stents in a high-risk group of diabetic patients. Previously, this had been analyzed only in substudies of larger trials or in clinical investigations enrolling a small number of patients.BACKGROUND:
Drug-eluting stents are highly effective in reducing the rate of in-stent restenosis.METHODS:
Two hundred patients with diabetes and de novo coronary artery lesions were enrolled in 16 centers 98 were randomly assigned to sirolimus-eluting stents (SES) and 102 received bare-metal stents (BMS). The primary end point was in-segment late luminal loss. Major adverse cardiac events (MACE) rate was analyzed at 30 days and 8 and 12 months.RESULTS:
The extent of in-segment late luminal loss in the SES group was 0.18 mm compared with 0.74 mm in the BMS group. In-segment restenosis was identified on follow-up angiography in 8.8% of the patients in SES and in 42.1% in BMS (p < 0.0001). Target lesion revascularization was performed in 5.3% of the patients in SES and in 21.1% of the patients in BMS (p = 0.002). The SES was effective in the treatment group with oral diabetic medication as well as in the insulin-dependent treatment group (3.6% SES vs. 38.8% BMS). There was no subacute stent thrombosis in the SES group up to 1 year. The MACE rate was not significantly different at 30 days. At 12 months, MACE rate was 14.7% in SES versus 35.8% in BMS.CONCLUSIONS:
The SES is safe and highly effective in patients with diabetes mellitus and coronary artery disease and associated with a significant decrease in the extent of late luminal loss.
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Base de dados:
MEDLINE
Assunto principal:
Stents
/
Sistemas de Liberação de Medicamentos
/
Sirolimo
/
Estenose Coronária
/
Complicações do Diabetes
/
Imunossupressores
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article