Clinical and neurocognitive correlates of insight in patients with bipolar I disorder in remission.
Acta Psychiatr Scand
; 117(1): 28-34, 2008 Jan.
Article
em En
| MEDLINE
| ID: mdl-17970840
ABSTRACT
OBJECTIVE:
The relationship between insight and neurocognition in bipolar disorder has not been clearly established.METHOD:
A neuropsychological battery assessing attention, mental control, perceptual-motor skills, executive functions, verbal fluency and abstraction, and visuo-spatial attention was administered to 50 bipolar remitted patients and 50 healthy controls. Insight was assessed with the Scale to Assess Unawareness of Mental Disorder.RESULTS:
Patients presented significantly worse neurocognitive performance. Insight was impaired in 60% of patients, and age, educational level, manic symptoms, age of disease onset, number of admissions, and performance on several neurocognitive tests correlated significantly with insight. A regression model revealed that age and Trail Making Test part B (TMT-B) performance accounted for 32% of the variance in overall illness awareness, while performance on the TMT-B alone accounted for 28% of the variance.CONCLUSION:
Impaired insight and neurocognitive dysfunction seem to be present in euthymic bipolar patients. Insight in bipolar disorder may be partially dependent on intact neurocognition.
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Base de dados:
MEDLINE
Assunto principal:
Transtorno Bipolar
/
Encéfalo
/
Transtornos Cognitivos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article